Factors Involved in the Pathogenesis of Psoriasis
نویسندگان
چکیده
Psoriasis is thought to be an autoimmune disease. Both innate and adaptive immune factors are involved in pathogenesis. Innate immune factors include neutrophils, dendritic cells, mast cells and keratinocytes as well as receptors that they express and cytokines they produce, and the coagulation and complement systems. The adaptive immune factors include mainly the T-lymphocyte subsets and their cytokines. Cytokines produced in both arms of the immune response and appear to play a major role in pathogenesis are TNF and IL-17. Innate and adaptive immune responses are interdependent and this review covers both arms of the immune response with respect to what is known about the pathogenesis of psoriasis.
منابع مشابه
Psoriasis and infestation with Malassezia
Abstract Background: Psoriasis is a chronic proliferative condition of the skin. Its accurate pathogenesis has not been known yet, but interactions between genes and environmental factors have been implicated in its initiation. The role of malassezia in psoriasis is still undetermined, but several reports have associated these lipophilic yeasts with the development of skin lesions in psoriasis...
متن کاملInverse correlation between glutathione peroxidase activity in psoriatic cutaneous lesions and the severity of the disease
Background: Psoriasis is a chronic-relapsing inflammatory skin disorder, in whose pathogenesis oxidative stress is suggested to be involved. Among different enzymes that play a role in maintaining the cellular redox balance, we aimed to assess the alteration of glutathione peroxidase (GPX) activity in cutaneous lesions and its correlation with the disease severity, firstly, to support the possi...
متن کاملThe role of Staphylococcus superantigens in chronic plaque type psoriasis
Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of superantigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal superantigens in the pathogenesis of psoriasis with identification of staphylococcal toxin levels in the skin lesions of p...
متن کاملSerum prolactin level in psoriasis
The recent report, “Serum prolactin level in psoriasis”, is very interesting 1. Ghiasi et al. concluded that “it seems that while intracutaneous prolactin may contribute to the pathogenesis of psoriasis, the probable role of pituitary-produced circulating prolactin in the disease process needs further investigation .” There are some concerns on this report. First, although Ghiasi et al. have st...
متن کاملEvaluation of the antioxidant defense status in psoriasis
Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system may be involvedin the pathogenesis of psoriasis. The aim of this study was toevaluate the a...
متن کاملRelationship of blood levels of vitamins A and E with psoriasis
Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013